Building and maintaining neuronal circuits in the olfactory system and in the dish
We have developed long range viral tracers that allow us to trace individual neurons over long tracts with high resolution and we used this system to define areas of the olfactory cortex that process odor information. Surprisingly we found that the map of information in the olfactory bulb is largely discarded in the cortex, in contrast with other sensory processing centers. Ongoing experiments are to analyze the role of genes and activity in building and maintaining these circuits, which has relevance for understanding sensory perception and for regenerative medicine. Other areas of interest are circuits in other regions of the brain that can be paired with generation of induced neurons in a dish to link human in vitro neurobiology with circuit function in in vivo in model systems.